When word got out that New Line Cinema was producing a movie titled Snakes On A Plane, starring Samuel Jackson, some people, assuming that no major studio would actually create a movie that stupid, thought it had to be a hoax. The minimalist plot outline (with bad grammar) added fuel to these suspicions:

On board a flight over the Pacific Ocean, an assassin, bent on killing a passenger who's a witness in protective custody, let loose a crate full of deadly snakes.

The hoax theory got a further boost when New Line decided not to launch an official website for the film. But now production photos from the set have been released, and Samuel Jackson has spoken publicly about it (refuting suggestions that the studio was going to rename the movie Pacific Air Flight 121), thereby tilting the balance in favor of the movie being real. I, for one, am looking forward to seeing it. But then, I'm easily entertained. Some of the sequel titles that people are inventing are pretty funny, such as Snakes on a Plane 2: Snakes on a Boat or Snakes on a Plane 9: Bears on a Train. According to the Urban Dictionary, The movie's title has also already entered popular speech as an expression of existential resignment:

snakes on a plane: A simple existential observation that has the same meaning as "Whaddya gonna do?" or "Shit Happens". Taken from the upcoming Samuel L. Jackson movie of the same name, and immortilised by screenwriter Josh Friedman on his blog post of Wednesday, August 17, 2005.
Guy 1: (irate) Dude, you just ran into the back of my SUV!
Guy 2: (calm) Snakes on a plane man. Snakes on a plane.